Peganum harmala (Syrian rue)
Seedpack 25 gram
IntroductionPeganum harmala, commonly called Esfand, wild rue, Syrian rue, African rue, or harmel, is a plant of the family Nitrariaceae. It is native from the eastern Iranian region west to India. Its common names refer to its resemblance to rue (which is not related).
Peganum harmala was first planted in the United States in 1928 in New Mexico by a farmer wanting to manufacture the dye "Iranian red" from its seeds. Since then, it has spread invasively to Arizona, California, Montana, Nevada, Oregon, Texas and Washington. "Because it is so drought tolerant, African rue can displace the native saltbushes and grasses growing in the salt-desert shrub lands of the Western U.S."
EffectsThe Syrian Rue plant (seeds, roots, etc) contain a variety of alkaloids, the most prominent of which are the harmala alkaloids: harmine, harmaline, and tetrahydroharmaline. According to Jonathan Ott, surveys done on the plant material have shown the B-carboline alkaloids range from 2-7% of the dry weight of the mature seeds with harmine making up the largest part of this. Syrian rue prevents the breakdown of monoamine neurotransmitters by inhibiting the action of monoamine oxidase enzymes, a process known as MAO-inhibition. This renders substances like DMT and 5-MeO-DMT orally active and makes a psilocybin mushroom experience last longer and become stronger.
How to use Peganum harmalaWhile some people report chewing and swallowing the seeds directly, or swallowing crushed seeds in capsules, simple acid extractions are often used. The plant is usually dosed orally with seeds or dosed orally as an extract. The extracted plant material can also be used in combination with vaporized DMT and can be used in orally-administered DMT. The combination oral dosage method requires a short duration to become functionally able to inhibit MAO.
AlkaloidsSome alkaloids of harmal seeds are monoamine oxidase A inhibitors (MAOI):
Vasicine (peganine), 0.25%
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