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Syrian rue (Peganum harmala)Seeds, 25 g

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Peganum harmala seeds have very strong MAO-inhibiting properties and give a totally different effect to the ayahuasca. Ayahuasca made with harmala seeds is not the same as the traditional brew with caapi vine
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Peganum harmala (Syrian Rue)

Peganum harmala is also known as Syrian Rue, Harmal or Esfand. The plant species has a centuries-old history of use in rituals by different cultures. The plant originates from Asia where it grows mainly in India and Pakistan.

Syrian Rue is still used for protection in Turkish houses. The plant cuttings are tied together and hung up. This protects the house and its occupants against the 'evil eye'. Syrian Rue is also still used in Iran, as incense. There, the plant serves to cleanse the mind and the environment.

In Western society, Syrian Rue is best known for its MAO (monoamine oxidase) inhibiting properties. As a result, among other ways it is used in Ayahuasca brews , as a replacement for Banisteriopsis caapi. The effects are quite different, however. The plant seeds are also popular because of their price. Syrian Rue is also available to you as part of the Worldherbals range.

Syrian Rue usage

You can simply eat the Syrian Rue seeds. You do this by grinding them between your teeth. You then mix your saliva with the crushed seeds for a couple of minutes before swallowing. You can also grind the seeds manually and use them in gelatin capsules. The advantage of both processes is that none of the effect is lost.

Due to its MAO-inhibiting properties, Syrian Rue is also used before taking DMT (dimethyltryptamine) substances, such as Chaliponga or Chacruna. DMT is broken down by enzymes after oral ingestion. Syrian Rue temporarily disables these enzymes. Take about 3 grams of the seeds 15 minutes to an hour before taking DMT. You will then experience the full psychedelic effect of the DMT. Do not increase the number of grams taken, as this will result in physical discomfort. Syrian Rue is also often used to intensify and prolong the effect of psychedelic mushrooms by up to two times.

You can also use Peganum harmala to make a herbal tea infusion. Although some of the effect is lost, it is better for the stomach. You can increase the effect by using 1-2 grams of extra seeds. Use 150 millilitres of water and 50 millilitres of lemon juice. Allow the finely ground seeds to simmer on a low heat for 15 minutes to half an hour. After straining the water, you can drink the infusion.

Some people use Syrian Rue as incense. This also has an MAO-inhibiting effect, albeit of much shorter duration than with oral ingestion.

Dose and Effects

Some people experiment with drinking tea made from Syrian Rue alone. This produces the so-called 'Harmal Buzz'. 'Buzz' because you experience a buzzing feeling in your body and mind. It can also have a psychedelic effect, such as visual distortions and unusual perceptions. The dosage varies from person to person but a dosage of 1 gram is recommended, especially to begin with. The following dosage recommendations apply to Syrian Rue:

  • Mild trip: 1 gram
  • Normal trip: 3 grams
  • Very strong trip (maximum dose): 5 grams

Effects and Side Effects

The alkaloids in Peganum harmala are mainly used for their MAO-inhibiting properties. This is what produces the effect of psychedelic plant species. DMT substances and psychedelic mushrooms are examples of this. The effects are prolonged and intensified. You can extend the hallucinogenic effects by up to four hours with Syrian Rue. As previously mentioned, you can also use Syrian Rue on its own, but pay close attention to the dosage. Too high a dosage can cause great physical discomfort.

Active alkaloids

Some alkaloids that are found in Peganum harmala seeds are strong monoamine oxidase A inhibitors (MAOIs):

  • Harman, 0.15%
  • Harmine, 4%
  • Harmaline, 5%
  • Harmalol, 4%
  • Tetrahydroharmine, 0.1%
  • Vasicine (peganine), 0.25%
  • Vasicinone, 0.0007%

Storage Recommendations

You can order 25 grams of Peganum harmala seeds from Worldherbals. These seeds are not suitable for use by people under the age of 18. Always store your Syrian Rue out of the reach and sight of children, and in a cool, dry place.


Please note: Peganum harmala contains MAO-inhibiting substances. The use of MAO-inhibiting plant species can be very dangerous in combination with psychoactive plant species, such as DMT. The same applies to its combination with certain foodstuffs.

Brand:Joy From Nature
Content:25 g

This products is legal in The Netherlands. Worldherbals cannot provide information about the legal status of this product in other countries. If you are not sure if the ordered product is legal in the country where it should be sent, please inform yourself about this issue with the authorities of the country itself. If you order this product to a country outside the Netherlands, you do this entirely at your own risk and you automatically safeguard Worldherbals from any form of legal liability.

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